RT Journal Article
SR Electronic
T1 Abnormal uterine bleeding induced by glucocorticoid treatment for pemphigus
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1025
OP 1028
DO 10.15537/smj.2016.9.14929
VO 37
IS 9
A1 Luo, Xiaobo
A1 Feng, Hui
A1 Jiang, Lu
A1 Chen, Qianming
YR 2016
UL http://smj.org.sa/content/37/9/1025.abstract
AB Glucocorticoids are the first-line treatment option for pemphigus. Moreover, abnormal uterine bleeding (AUB) is a rarely reported side effect of glucocorticoid treatment that usually manifests as abnormal and excessive endometrial bleeding; in fact, AUB can be induced by the systemic or topical application of glucocorticoids. In the present report, we describe the cases of 3 patients with pemphigus who developed AUB following glucocorticoid administration. It is important to note that the administration mode of glucocorticoids, and the onset time and duration of AUB differed among these patients. Thus, we propose the following treatment algorithm for AUB following glucocorticoid administration: 1. perform a gynecological and physical examination to exclude organic diseases. 2. continue glucocorticoid treatment. 3. if AUB persists, change the mode of administration of glucocorticoids. 4. if AUB still persists, despite these measures, completely withdraw treatment with glucocorticoids and use non-glucocorticoid treatments.