PT  - JOURNAL ARTICLE
AU  - Chen, Peng
AU  - Sun, Ye-Qi
AU  - Yang, Guo-Ping
AU  - Li, Rong
AU  - Pan, Jie
AU  - Zhou, Yu-Sheng
TI  - Influence of the CYP4F2 polymorphism on the risk of hemorrhagic complications in coumarin-treated patients
AID  - 10.15537/smj.2016.4.14036
DP  - 2016 Apr 01
TA  - Saudi Medical Journal
PG  - 361--368
VI  - 37
IP  - 4
4099  - http://smj.org.sa/content/37/4/361.short
4100  - http://smj.org.sa/content/37/4/361.full
SO  - Saudi Med J2016 Apr 01; 37
AB  - Objectives: To evaluate the impact of the CYP4F2 polymorphism on bleeding complications and over-anticoagulation due to coumarin.Methods: A comprehensive literature search was performed to look for eligible studies published prior to February 2015 in EMBASE and PubMed. References were strictly identified by inclusion and exclusion criteria, and authors of primary studies were consulted for additional information and data. Revman 5.3 software was used to analyze the impact of the CYP4F2 polymorphism on hemorrhagic complications and over-anticoagulation events (international normalized ratio >4).Results: Eight studies involving 3,101 samples met the specified inclusion criteria. Compared with wild-type homozygotes (CYP4F2*1*1), carriers of the CYP4F2*3 variant had no significant effects on total bleeding events (odds ratio [OR]: 0.86; 95% confidence interval [CI]: 0.71-1.05; p=0.15), major hemorrhage complications in coumarin users (OR: 0.80; 95% CI: 0.64-1.01; p=0.06). Patients carried CYP4F2*3 also had nonsignificant associations with the risk of over-anticoagulation (relative risk [RR]: 079; 95% CI: 0.59-1.06; p=0.12). We found a lower risk in patients with homozygotes for CYP4F2*3, but there was no statistical significance (RR: 0.66; 95% CI: 0.43-1.01; p=0.05).Conclusion: This meta-analysis indicated the impact of the CYP4F2 polymorphism on bleeding complications and over-anticoagulation in coumarin-treated patients failed to reach the level of statistical significance. However, large-scale and well designed studies are necessary to determine conclusively the association between the CYP4F2 polymorphism and hemorrhage risk.