RT Journal Article
SR Electronic
T1 Pathogenic role of platelets in rheumatoid arthritis and systemic autoimmune diseases
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 354
OP 360
DO 10.15537/smj.2016.4.14768
VO 37
IS 4
A1 Harifi, Ghita
A1 Sibilia, Jean
YR 2016
UL http://smj.org.sa/content/37/4/354.abstract
AB Well-recognized for their role in vascular homoeostasis, platelets may play a major role in inflammation and immunomodulation. Substantial data are emerging on the pathogenic involvement of platelets in inflammatory arthritis and autoimmune diseases, indicating the existence of crosstalk between the coagulation and inflammation system. Upon activation, platelets release pro-inflammatory platelets microparticles, which interact with leucocytes leading to joint and systemic inflammation in rheumatoid arthritis. Platelets activation by immune complexes activate dendritic cells promoting the secretion of interferon alpha, which has a key role in the development of systemic lupus erythematous. In this review, we discuss the current data on the role of platelets in the pathophysiology of inflammatory arthritis and various autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis.