RT Journal Article
SR Electronic
T1 Birth prevalence of non-syndromic orofacial clefts in Saudi Arabia and the effects of parental consanguinity
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1076
OP 1083
DO 10.15537/smj.2015.9.11823
VO 36
IS 9
A1 Sabbagh, Heba J.
A1 Innes, Nicola P.
A1 Sallout, Bahauddin I.
A1 Alamoudi, Najlaa M.
A1 Hamdan, Mustafa A.
A1 Alhamlan, Nasir
A1 Al-Khozami, Amaal I.
A1 Abdulhameed, Fatma D.
A1 Al-Aama, Jumana Y.
A1 Mossey, Peter A.
YR 2015
UL http://smj.org.sa/content/36/9/1076.abstract
AB Objectives: To describe the characteristics and prevalence of non-syndromic orofacial clefting (NSOFC) and assess the effects of parental consanguinity on NSOFC phenotypes in the 3 main cities of Saudi Arabia.Methods: All infants (114,035) born at 3 referral centers in Riyadh, and 6 hospitals in Jeddah and Madinah between January 2010 and December 2011 were screened. The NSOFC cases (n=133) were identified and data was collected through clinical examination and records, and information on consanguinity through parent interviews. The diagnosis was confirmed by reviewing medical records and contacting the infants’ pediatricians. Control infants (n=233) matched for gender and born in the same hospitals during the same period, were selected.Results: The prevalence of NSOFC was 1.07/1000 births in Riyadh, and 1.17/1000 births overall; cleft lip (CL) was 0.47/1000 births, cleft lip and palate (CLP) was 0.42/1000 births, and cleft palate (CP) was 0.28/1000 births. Cleft palate was significantly associated with consanguinity (p=0.047, odds ratio: 2.5, 95% confidence interval: 1 to 6.46), particularly for first cousin marriages.Conclusion: The birth prevalence of NSOFC in Riyadh alone, and in the 3 main cities of Saudi Arabia were marginally lower than the mean global prevalence. While birth prevalence for CLP was comparable to global figures, the CL:CLP ratio was high, and only CP was significantly associated with consanguinity.