RT Journal Article
SR Electronic
T1 Association of XRCC1 Trp194 allele with risk of breast cancer, and Ki67 protein status in breast tumor tissues
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 624
OP 630
DO 10.15537/smj.2016.6.13540
VO 37
IS 6
A1 Jalali, Chiya
A1 Ghaderi, Bayazid
A1 Amini, Sabrieh
A1 Abdi, Mohammad
A1 Roshani, Daem
YR 2016
UL http://smj.org.sa/content/37/6/624.abstract
AB Objectives: To evaluate the role of this polymorphism as a risk factor for breast cancer in Kurdish patients and to investigate the possible association between Arg194Trp x-ray repair cross-complementing group 1 (XRCC1) gene polymorphisms with clinical and histopathological outcomes of patients with breast cancer.Methods: A total of 100 breast cancer patients and 200 cancer-free controls in Kurdish population of Kurdistan state admitted to Tohid Hospital, Sanandaj, Kurdistan, Iran between January 2012 and May 2015 were enrolled in this cross-sectional study. Tissue expression of estrogen receptor (ER), progesteron receptor (PR), human epidermal growth factor receptor 2 (Her2/neu), and Ki67 were evaluated by immunohistochemistry (IHC). The Arg194Trp genotypes were determined by polymerase chain reaction- restriction fragment length polymorphism method.Results: Our data showed that the risk for breast cancer increased significantly among the Trp variant of XRCC1. Statistically significant association was found between codon 194 polymorphisms and tissue expression of Ki67.Conclusion: The Trp allele of codon 194 XRCC1 is a potential risk factor for breast cancer in Kurdish ethnicity. Furthermore, effect of this polymorphism on clinical and histological features of breast cancer was significant.