RT Journal Article SR Electronic T1 An extraordinary case of syphilis presenting with a labial ulcer JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 1261 OP 1264 DO 10.15537/smj.2016.11.15674 VO 37 IS 11 A1 Filiz T. Demir A1 Kenyul Salaeva A1 Ilknur K. Altunay A1 Ozben Yalcın YR 2016 UL http://smj.org.sa/content/37/11/1261.abstract AB In the differential diagnosis of patients with ulcers on the lips characteristics like the duration of the ulcer, number, size, depth, shape, base, margins, and distribution are considered. Such ulcers arise from many diseases particularly, viral and bacterial infections, malignancies can also be responsible. Classic syphilitic chancres are painless erosions settled on hard papule; these are evident in the genital area in more than 90% of patients. This study describes a case of a 38-year-old female patient presenting with a painful ulcer covering 3 quarters of the upper lip showing settlement on erythematous, edematous, and indurated plaque covered with hemorrhagic crusts. The aim of this study was to consider differences between the classic syphilitic chancre typically found in the genital region from extragenital chancres and to raise awareness of the possibility of primary syphilis when patients present with painful ulcers on the lip.