@article {K{\i}l{\i}c1191, author = {Ertugrul K{\i}l{\i}c and Bar{\i}s Demiriz and Nurg{\"u}l Is{\i}kay and Abdullah E. Y{\i}ld{\i}r{\i}m and Selman Can and Cem Basmac{\i}}, title = {Alfentanil versus ketamine combined with propofol for sedation during upper gastrointestinal system endoscopy in morbidly obese patients}, volume = {37}, number = {11}, pages = {1191--1195}, year = {2016}, doi = {10.15537/smj.2016.11.14557}, publisher = {Saudi Medical Journal}, abstract = {Objectives: To observe the effects of both propofol/alfentanil and propofol/ketamine on sedation during upper gastrointestinal system endoscopy in morbidly obese patients (UGSEMOP).Methods: In a prospective, double-blinded, randomized clinical study, 52 patients scheduled for UGSEMOP were assigned to either group A (n=26; 10 {\textmu}g/kg intravenous [IV] alfentanil) or group K (n=26; 0.5 mg/kg IV ketamine). Each patient was administered 0.7 mg/kg propofol for induction. If it was needed, the patients were administered an additional dose of IV propofol. This study was performed in Sehitkamil State Hospital, Gaziantep, Turkey, between January 2014-2015. Total propofol consumption, time to achieve Modified Aldrete Scores (MAS) of 5 and 10 following the procedure, physician and patient satisfaction scores, and instances of side effects, such as bradycardia and hypotension were recorded.Results: Time to onset of sedation and duration of sedation were both significantly shorter in group A. Patients in group A also required less time to achieve an MAS of 5. Total propofol consumption was significantly lower in group A.Conclusion: Both propofol/alfentanil and propofol/ketamine combinations provided appropriate hypnosis and analgesia during UGSEMOP. However, propofol consumption was significantly higher using the propofol/ketamine combination.}, issn = {0379-5284}, URL = {https://smj.org.sa/content/37/11/1191}, eprint = {https://smj.org.sa/content/37/11/1191.full.pdf}, journal = {Saudi Medical Journal} }