PT  - JOURNAL ARTICLE
AU  - Kılıc, Ertugrul
AU  - Demiriz, Barıs
AU  - Isıkay, Nurgül
AU  - Yıldırım, Abdullah E.
AU  - Can, Selman
AU  - Basmacı, Cem
TI  - Alfentanil versus ketamine combined with propofol for sedation during upper gastrointestinal system endoscopy in morbidly obese patients
AID  - 10.15537/smj.2016.11.14557
DP  - 2016 Nov 01
TA  - Saudi Medical Journal
PG  - 1191--1195
VI  - 37
IP  - 11
4099  - http://smj.org.sa/content/37/11/1191.short
4100  - http://smj.org.sa/content/37/11/1191.full
SO  - Saudi Med J2016 Nov 01; 37
AB  - Objectives: To observe the effects of both propofol/alfentanil and propofol/ketamine on sedation during upper gastrointestinal system endoscopy in morbidly obese patients (UGSEMOP).Methods: In a prospective, double-blinded, randomized clinical study, 52 patients scheduled for UGSEMOP were assigned to either group A (n=26; 10 µg/kg intravenous [IV] alfentanil) or group K (n=26; 0.5 mg/kg IV ketamine). Each patient was administered 0.7 mg/kg propofol for induction. If it was needed, the patients were administered an additional dose of IV propofol. This study was performed in Sehitkamil State Hospital, Gaziantep, Turkey, between January 2014-2015. Total propofol consumption, time to achieve Modified Aldrete Scores (MAS) of 5 and 10 following the procedure, physician and patient satisfaction scores, and instances of side effects, such as bradycardia and hypotension were recorded.Results: Time to onset of sedation and duration of sedation were both significantly shorter in group A. Patients in group A also required less time to achieve an MAS of 5. Total propofol consumption was significantly lower in group A.Conclusion: Both propofol/alfentanil and propofol/ketamine combinations provided appropriate hypnosis and analgesia during UGSEMOP. However, propofol consumption was significantly higher using the propofol/ketamine combination.