PT  - JOURNAL ARTICLE
AU  - Mahmood Rasool
AU  - Arif Malik
AU  - Uzma Jabbar
AU  - Irshad Begum
AU  - Mahmood H. Qazi
AU  - Muhammad Asif
AU  - Muhammad I. Naseer
AU  - Shakeel A. Ansari
AU  - Jummanah Jarullah
AU  - Absarul Haque
AU  - Mohammad S. Jamal
TI  - Effect of iron overload on renal functions and oxidative stress in beta thalassemia patients
AID  - 10.15537/smj.2016.11.16242
DP  - 2016 Nov 01
TA  - Saudi Medical Journal
PG  - 1239--1242
VI  - 37
IP  - 11
4099  - http://smj.org.sa/content/37/11/1239.short
4100  - http://smj.org.sa/content/37/11/1239.full
SO  - Saudi Med J2016 Nov 01; 37
AB  - Objectives: To check the amount of cellular damage caused by serial transfusions of blood in thalassemia patients.Methods: A cross-sectional study was conducted in the University of Lahore, Lahore, Pakistan between August 2012 and December 2012. A total of 43 thalassemia patients underwent at least 10 blood transfusions. Comprehensive biochemical analysis of blood was performed to record the levels of creatinine, urea, uric acid, albumin, liver function tests, malondialdehyde (MDA), and ferritin.Results: Serum creatinine (0.732±0.23mg/dl) and uric acid (6.7±0.94mg/dl, p<0.05) were significantly higher in patient groups as compared with the control. Ferritin levels were significantly higher in patients as compared with the control (3103.9±1747.4, p<0.05). Hemoglobin levels were observed in controls 14±1.3g/dl and in patients 7.1±1.03g/dl. No clear relationship exists between age and hematological parameters of thalassemic patients. Serum ferritin level is positively related with serum alanine transaminase, aspartate aminotransferase, and alkaline phosphatase and MDA (p<0.05).Conclusion: Serum MDA and serum ferritin of patients (r=0.593, p<0.05) reflects that both are crucial parameters estimating the cellular damage in patients suffering from thalassemia.