RT Journal Article
SR Electronic
T1 Effect of iron overload on renal functions and oxidative stress in beta thalassemia patients
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1239
OP 1242
DO 10.15537/smj.2016.11.16242
VO 37
IS 11
A1 Mahmood Rasool
A1 Arif Malik
A1 Uzma Jabbar
A1 Irshad Begum
A1 Mahmood H. Qazi
A1 Muhammad Asif
A1 Muhammad I. Naseer
A1 Shakeel A. Ansari
A1 Jummanah Jarullah
A1 Absarul Haque
A1 Mohammad S. Jamal
YR 2016
UL http://smj.org.sa/content/37/11/1239.abstract
AB Objectives: To check the amount of cellular damage caused by serial transfusions of blood in thalassemia patients.Methods: A cross-sectional study was conducted in the University of Lahore, Lahore, Pakistan between August 2012 and December 2012. A total of 43 thalassemia patients underwent at least 10 blood transfusions. Comprehensive biochemical analysis of blood was performed to record the levels of creatinine, urea, uric acid, albumin, liver function tests, malondialdehyde (MDA), and ferritin.Results: Serum creatinine (0.732±0.23mg/dl) and uric acid (6.7±0.94mg/dl, p<0.05) were significantly higher in patient groups as compared with the control. Ferritin levels were significantly higher in patients as compared with the control (3103.9±1747.4, p<0.05). Hemoglobin levels were observed in controls 14±1.3g/dl and in patients 7.1±1.03g/dl. No clear relationship exists between age and hematological parameters of thalassemic patients. Serum ferritin level is positively related with serum alanine transaminase, aspartate aminotransferase, and alkaline phosphatase and MDA (p<0.05).Conclusion: Serum MDA and serum ferritin of patients (r=0.593, p<0.05) reflects that both are crucial parameters estimating the cellular damage in patients suffering from thalassemia.