@article {Liu839, author = {Chenggui Liu and Yinzhong Yang and Duanliang Peng and Linong Chen and Jun Luo}, title = {Hyperhomocysteinemia as a metabolic disorder parameter is independently associated with the severity of coronary heart disease}, volume = {36}, number = {7}, pages = {839--846}, year = {2015}, doi = {10.15537/smj.2015.7.11453}, publisher = {Saudi Medical Journal}, abstract = {Objectives: To study the associations between hyperhomocysteinemia (HHcy) and the severity of coronary heart disease (CHD).Methods: We retrospectively analyzed metabolic parameters, anthropometric variables, and life style habits in 292 CHD patients of different categories, and 100 controlled non-CHD patients with chest pain symptoms who were hospitalized in the Department of Cardiovascular Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People{\textquoteright}s Hospital, Chengdu, China between October 2013 and September 2014.Results: The prevalence of HHcy in CHD patients was 79.1\%, while only 5\% of non-CHD patients had elevated serum homocysteine (Hcy) concentrations. The prevalence of HHcy significantly increased from 5\% in non-CHD controls to 66\% in the stable angina pectoris (SAP) group, to 81.9\% in the unstable angina pectoris group, and to 93.15\% in the acute myocardial infarction (AMI) group (p\<0.001). After adjusting for confounding factors, multivariate logistic regression analysis showed that HHcy was independently associated with CHD category (AMI versus SAP, odds ratio [6.38], 95\% confidence interval; 1.18-34.46). The Hcy was negatively correlated with folic acid (r=-0.67, p\<0.001) and vitamin B12 (r=-0.56, p\<0.001). Of the CHD patients with HHcy, 51.1\% had low folic acid and 42\% had low vitamin B12, 7 or 5 times higher than that of CHD patients with normal-low Hcy concentrations (p\<0.001).Conclusion: Hyperhomocysteinemia is independently associated with the severity of CHD, and significantly correlated with low status of folic acid and vitamin B12 in CHD patients.}, issn = {0379-5284}, URL = {https://smj.org.sa/content/36/7/839}, eprint = {https://smj.org.sa/content/36/7/839.full.pdf}, journal = {Saudi Medical Journal} }