PT  - JOURNAL ARTICLE
AU  - Ghahremanfard, Farahnaz
AU  - Semnani, Vahid
AU  - Ghorbani, Raheb
AU  - Malek, Farhad
AU  - Behzadfar, Ali
AU  - Zahmatkesh, Mehrdad
TI  - Effects of cigarette smoking on morphological features of platelets in healthy men
AID  - 10.15537/smj.2015.7.11026
DP  - 2015 Jul 01
TA  - Saudi Medical Journal
PG  - 847--850
VI  - 36
IP  - 7
4099  - http://smj.org.sa/content/36/7/847.short
4100  - http://smj.org.sa/content/36/7/847.full
SO  - Saudi Med J2015 Jul 01; 36
AB  - Objectives: To assess the effects of cigarette smoking on thrombocytopoiesis and some platelet morphological parameters in healthy male smokers.Methods: In this cross-sectional study, 542 consecutive healthy men (aged 20 to 88 years), referred to the laboratory of Fatemieh Hospital, Semnan, Iran, between November 2011 and November 2012 for checking up were enrolled. The subjects were divided into 2 groups of smokers (n=258 with frequency of 10 or more cigarette per day with more than 12 months duration of smoking) and non-smokers (n=284). The blood samples were extracted to examine values of platelet indices using an ABX Micros 60 cell counter.Results: Comparing platelet indices across smokers and non-smokers showed that the mean platelet count was statistically significantly higher in adult smokers than in nonsmokers (264.1 ± 81.2/µl versus 247.7 ± 83.9/µl, p=0.021), while the mean plateletcrit value was contrarily lower in the adult smokers (18.0 ± 12.0% versus 25.0 ± 10.0%, p<0.001). Other platelet indicators were not discrepant between the smokers and non-smokers.Conclusion: Cigarette smoking in healthy individuals results in significant and considerable effects on platelet morphological indices. The mean platelet count is significantly increased, and plateletcrit values are reduced, compared with non-smoking status.