RT Journal Article
SR Electronic
T1 Effects of cigarette smoking on morphological features of platelets in healthy men
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 847
OP 850
DO 10.15537/smj.2015.7.11026
VO 36
IS 7
A1 Farahnaz Ghahremanfard
A1 Vahid Semnani
A1 Raheb Ghorbani
A1 Farhad Malek
A1 Ali Behzadfar
A1 Mehrdad Zahmatkesh
YR 2015
UL http://smj.org.sa/content/36/7/847.abstract
AB Objectives: To assess the effects of cigarette smoking on thrombocytopoiesis and some platelet morphological parameters in healthy male smokers.Methods: In this cross-sectional study, 542 consecutive healthy men (aged 20 to 88 years), referred to the laboratory of Fatemieh Hospital, Semnan, Iran, between November 2011 and November 2012 for checking up were enrolled. The subjects were divided into 2 groups of smokers (n=258 with frequency of 10 or more cigarette per day with more than 12 months duration of smoking) and non-smokers (n=284). The blood samples were extracted to examine values of platelet indices using an ABX Micros 60 cell counter.Results: Comparing platelet indices across smokers and non-smokers showed that the mean platelet count was statistically significantly higher in adult smokers than in nonsmokers (264.1 ± 81.2/µl versus 247.7 ± 83.9/µl, p=0.021), while the mean plateletcrit value was contrarily lower in the adult smokers (18.0 ± 12.0% versus 25.0 ± 10.0%, p<0.001). Other platelet indicators were not discrepant between the smokers and non-smokers.Conclusion: Cigarette smoking in healthy individuals results in significant and considerable effects on platelet morphological indices. The mean platelet count is significantly increased, and plateletcrit values are reduced, compared with non-smoking status.