RT Journal Article
SR Electronic
T1 Roles of nucleolin
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1312
OP 1318
DO 10.15537/smj.2016.12.15972
VO 37
IS 12
A1 Chen, Zhuo
A1 Xu, XinHua
YR 2016
UL http://smj.org.sa/content/37/12/1312.abstract
AB Nucleolin, a multifunctional protein distributed in the nucleolus, participates in many modulations including rDNA transcription, RNA metabolism, and ribosome assembly. Nucleolin is also found in the cytoplasm and on the cell membrane, and surface nucleolin can bind to various ligands to affect many physiological functions. The expression and localization of nucleolin is often abnormal in cancers, as the differential distribution of nucleolin in cancer can influence the carcinogenesis, proliferation, survival, and metastasis of cancer cells, leading to the cancer progression. Thus, nucleolin may be a novel and promising target for anti-cancer treatment. Here, we describe how nucleolin act functions in cancer development and describe nucleolin-dependent anti-cancer therapies.