RT Journal Article SR Electronic T1 Heat related illnesses JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 1195 OP 1201 DO 10.15537/smj.2019.12.24727 VO 40 IS 12 A1 Anas A. Khan YR 2019 UL http://smj.org.sa/content/40/12/1195.abstract AB Climate change is the most challenging natural calamity of chronic nature that presents intense episodes of heat waves, and events. Effects of heat waves and increasing average temperature on heat-related illnesses (HRIs) demand a review of existing preventive and treatment strategies to direct future research. Heat-related illnesses are presented as minor to severe life-threatening conditions. Despite the understanding of the pathophysiology of HRI, pharmacological interventions are limited. Prevention is the best strategy against HRI. There is a dearth of epidemiological studies that reviewed the effect of pharmacological interventions on mortality, and there remains a need to identify critical key components other than inflammatory modulators, which can be targeted to decrease HRI.