PT  - JOURNAL ARTICLE
AU  - Aktug-Demir, Nazlim
AU  - Kolgelier, Servet
AU  - Ozcimen, Serap
AU  - Sumer, Sua
AU  - Demir, Lutfi S.
AU  - Inkaya, Ahmet C.
TI  - Diagnostic clues for spondylitis in acute brucellosis
DP  - 2014 Aug 01
TA  - Saudi Medical Journal
PG  - 816--820
VI  - 35
IP  - 8
4099  - http://smj.org.sa/content/35/8/816.short
4100  - http://smj.org.sa/content/35/8/816.full
SO  - Saudi Med J2014 Aug 01; 35
AB  - OBJECTIVES: To determine the diagnostic factors for brucellar spondylitis.METHODS: This retrospective study included 227 consecutive brucellosis patients admitted to the Infectious Diseases and Clinical Microbiology clinics of Adiyaman State Hospital and Adiyaman 82nd Year State Hospital, Adiyaman, Turkey between January 2010 and December 2012. Acute brucellosis was diagnosed by standard tube agglutination test and/or growth of Brucella spp. in appropriately prepared culture media (Bactec). Brucellar spondylitis was diagnosed and followed-up with contrast-enhanced magnetic resonance imaging.RESULTS: Among the 227 brucellosis patients included, 88 (38.8%) were male, and 139 (61.2%) were female. Brucellar spondylitis was detected in 54 patients (23.7%). Brucellar spondylitis patients had higher mean age, higher fever, and higher blood culture positivity rate when compared with brucellosis patients (p=0.001, p=0.001, and p=0.001). Logistical regression analysis determined that male gender (OR: 3.006), older age (OR: 1.025), erythrocyte sedimentation rate (ESR) (OR: 1.067), high fever at the time of admission (OR: 2.550), and positive blood cultures for Brucella spp. (OR: 4.003) values were independently associated with brucellar spondylitis. However, high C-reactive protein (CRP) levels (OR: 0.971) were not found as a risk factor for brucellar spondylitis. Conclusions: The results of this study shows that the risk of developing brucellar spondylitis is high in patients with acute brucellosis, who are at advanced age, who have high fever, that have Brucella spp. growth in their blood culture that has a high ESR value, and who are male.