PT  - JOURNAL ARTICLE
AU  - Usta, Ufuk
AU  - Tastekin, Ebru
AU  - Isler, Erhan
AU  - Kutlu, Ali K.
AU  - Oz Puyan, Fulya
TI  - Histopathological and immune alterations in autopsied kidneys
DP  - 2014 Nov 01
TA  - Saudi Medical Journal
PG  - 1331--1338
VI  - 35
IP  - 11
4099  - http://smj.org.sa/content/35/11/1331.short
4100  - http://smj.org.sa/content/35/11/1331.full
SO  - Saudi Med J2014 Nov 01; 35
AB  - OBJECTIVES: To collect data on all detectable histologic and immune alterations from the kidneys of 55 autopsy cases.METHODS: This prospective study was carried out at the Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey. Fifty-five cases were subjected to the study among 248 autopsies that were performed in 2011 and 2012. All kidney samples were evaluated under a light microscope and fresh tissue samples were used for immunofluorescence microscopy. Immunohistochemically kappa (κ) and lambda (λ) antibodies were applied to the tissue sections. The glomerular, tubulo-interstitial, and vascular alterations, as well as immune depositions were noted.RESULTS: The microscopic morphology was close to normal histology in only 23 cases, and 23 cases had glomerular alterations. Nineteen cases had at least one immune deposition. There was immunoglobulin A deposition in 13 cases, and 9 cases showed positivity for both κ and λ immunohistochemically, and there was no clonal positivity.CONCLUSION: The most striking outcome of our study is the high rate of immune depositions. There was also a significant number of glomerular and non-glomerular renal alterations.