PT  - JOURNAL ARTICLE
AU  - Albasri, Abdulkader
AU  - Hussainy, Akbar S.
AU  - Sundkji, Ibrahim
AU  - Alhujaily, Ahmed
TI  - Histopathological features of breast cancer in Al-Madinah region of Saudi Arabia
DP  - 2014 Dec 01
TA  - Saudi Medical Journal
PG  - 1489--1493
VI  - 35
IP  - 12
4099  - http://smj.org.sa/content/35/12/1489.short
4100  - http://smj.org.sa/content/35/12/1489.full
SO  - Saudi Med J2014 Dec 01; 35
AB  - OBJECTIVES: To observe the frequency of breast cancer among Saudi patients and to highlight the age variations and features of advanced cancer.METHODS: A retrospective study of breast cancer biopsies from all Saudi patients performed between January 2006 and December 2013 in King Fahad Hospital, Al-Madinah, Kingdom of Saudi Arabia. All the available demographic and tumor related data was analyzed.RESULTS: Of 1005 breast tissues reviewed, 982 specimens were from female, and 23 from male patients. In females, 398 specimens (40.5%) were diagnosed as malignant. Invasive ductal carcinoma (IDC) (85.2%) was most common, followed by ductal carcinoma in situ (8%), and invasive lobular carcinoma (2.7%). The mean age of Saudi females with IDC was 46.9 years. Approximately 48.7% IDC were Grade III tumors. A tumor size >2.5 cm was found in 61.1% patients, whereas axillary nodal metastasis was present in 57.1% and lympho-vascular invasion in 64.1% who underwent axillary nodal dissection. In males, 4 specimens (17.4%) were malignant (all IDC).CONCLUSION: Our finding are consistent with previous reports of breast cancer being diagnosed in younger age group, in advanced stages, and with features of aggressive behavior; which signals the urgency for implementation of breast screening programs.