PT  - JOURNAL ARTICLE
AU  - Hong, Jin-Quan
AU  - He, He-Fan
AU  - Chen, Zhi-Yuan
AU  - Du, Zhen-Shuang
AU  - Liu, Wei-Feng
AU  - Weng, Pei-Qing
AU  - Huang, Hao-Bo
TI  - Comparison of stroke volume variation with pulse pressure variation as a diagnostic indicator of fluid responsiveness in mechanically ventilated critically ill patients
DP  - 2014 Mar 01
TA  - Saudi Medical Journal
PG  - 261--268
VI  - 35
IP  - 3
4099  - http://smj.org.sa/content/35/3/261.short
4100  - http://smj.org.sa/content/35/3/261.full
SO  - Saudi Med J2014 Mar 01; 35
AB  - OBJECTIVE: To compare the diagnostic accuracy of stroke volume variation (SVV) and pulse pressure variation (PPV) in studies that examined both parameters in the same patient population.METHODS: Literature search was conducted in PubMed, EMBASE, CINAHL, and Google Scholar. Receiver operator characteristic (ROC) curves were examined, and summary ROC curves were plotted.RESULTS: The study was conducted from January to July 2013 in The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China. The meta-analysis of 19 studies published during the years 2005 and 2013 revealed a high degree of diagnostic accuracy of both SVV and PPV in predicting fluid responsiveness. The sensitivity and specificity of both the parameters were observed above 80% in a heterogeneous group of over 850 patients of which 55% responded to fluid challenge. The following values along with 95% confidence interval were noticed: SVV - sensitivity 82 (59-93%) and specificity 84 (62-95%), PPV - sensitivity 84 (62-95%) and specificity 83 (58-94%). Area under the curve values obtained in the pooled analysis were 0.84 (0.79-0.89) for SVV, and 0.88 (0.84-0.92) for PPV.CONCLUSION: Both SVV and PPV exhibit a high degree of diagnostic accuracy in predicting the success or failure of a fluid challenge in hemodynamically unstable critically ill patients under controlled mechanical ventilation.