PT  - JOURNAL ARTICLE
AU  - Huan, Cheng
AU  - Han, Tao
AU  - Ju, Ying
AU  - Qu, Yuan-Ming
TI  - Characteristics of mixed prolactin and adrenocorticotropin secreting pituitary adenomas and the differences in patients with merely prolactin-secreting adenomas
DP  - 2014 Mar 01
TA  - Saudi Medical Journal
PG  - 248--254
VI  - 35
IP  - 3
4099  - http://smj.org.sa/content/35/3/248.short
4100  - http://smj.org.sa/content/35/3/248.full
SO  - Saudi Med J2014 Mar 01; 35
AB  - OBJECTIVE: To evaluate the characteristics of pituitary adenomas that produce both prolactin and adrenocorticotropin.METHODS: Between 2002 and 2011, we reviewed the data of 336 patients undergoing transsphenoidal surgery at Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China. Patients were divided into 2 subgroups: patients with mixed prolactin and adrenocorticotropin secreting adenomas, and patients with merely prolactin-secreting adenomas. Clinical and endocrinological data, imaging, histopathological reports, and outcomes were reviewed. Differences between the 2 groups were statistically analyzed, and p<0.05 was considered statistically significant.RESULTS: Compared to patients with merely prolactin-secreting adenomas, patients with mixed prolactin and adrenocorticotropin secreting adenomas were younger (p<0.001), had higher incidences of headaches and dizziness (p=0.021), progressive obesity (p<0.001), menstrual disorders (p=0.006), polyuria and polydipsia (p<0.001), hypertension (p=0.001), diabetes mellitus (p=0.001), and had higher rates of postoperative hyponatremia (p<0.001). Recurrence rates in patients with prolactin-secreting adenomas were 19.1% and patients with mixed prolactin and adrenocorticotropin secreting adenomas were 35.1% (p=0.023). However, the endocrine normalization rate in mixed prolactin and adrenocorticotropin secreting adenomas was lower (p=0.004).CONCLUSION: Careful long-term follow-up is needed for patients with mixed prolactin and adrenocorticotropin secreting adenomas.