PT  - JOURNAL ARTICLE
AU  - Xu, Xin-Hua
AU  - Liu, Yang
TI  - Study of the correlationship link between microRNAs and nasopharyngeal carcinoma
DP  - 2014 Apr 01
TA  - Saudi Medical Journal
PG  - 329--335
VI  - 35
IP  - 4
4099  - http://smj.org.sa/content/35/4/329.short
4100  - http://smj.org.sa/content/35/4/329.full
SO  - Saudi Med J2014 Apr 01; 35
AB  - Nasopharyngeal carcinoma (NPC) is a polygenic disease related to a variety of factors. With the development of the microRNAs (miRNAs) technique, researchers found a close link between miRNAs and NPC. Differentially expressed miRNAs exist in NPC and normal nasopharyngeal tissues; radiotherapy and chemotherapy also affect the expression of miRNAs in NPC tissues. Further studies showed that dysregulation and ectopic expression of miRNAs were involved in the occurrence and development of NPC by affecting the expression of oncogenes or tumor suppressor genes, or acting on relevant signal transduction pathways. It is of great significance to investigate the miRNAs related to the occurrence and development of NPC for the prevention and treatment of NPC.