RT Journal Article
SR Electronic
T1 Immature reticulocyte fraction is an early predictor of bone marrow recovery post chemotherapy in patients with acute leukemia
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 346
OP 349
VO 35
IS 4
A1 Raja-Sabudin, RajaZahratul A.
A1 Othman, Ainoon
A1 Ahmed-Mohamed, KhalidAwad E.
A1 Ithnin, Azlin
A1 Alauddin, Hafiza
A1 Alias, Hamidah
A1 Abdul-Latif, Zarina
A1 Das, Srijit
A1 Abdul-Wahid, Fadilah S.
A1 Hussin, Noor H.
YR 2014
UL http://smj.org.sa/content/35/4/346.abstract
AB OBJECTIVE: To establish the benefits of immature reticulocyte fraction (IRF) measurement using an automated hematology cells analyzer over absolute neutrophil count (ANC) in predicting bone marrow recovery post induction chemotherapy.METHODS: A prospective observational study was carried out in the Departments of Pathology, Medicine, and Pediatrics, Universiti Kebangsaan Malaysia, Medical Center (UKMMC), Kuala Lumpur, Malaysia during a period of 19 months from April 2009 to December 2010 to assess the bone marrow recovery in patients with acute leukemia. A total of 22 patients in remission induction phases were enrolled in this study. The blood specimens were collected from day zero after chemotherapy, and every 3 days until patients recovered hematologically. All blood samples were measured for ANC and IRF using an automated hematology analyzer (Beckman-Coulter LH750).RESULTS: The percentage of patients showing IRF recovery earlier than ANC recovery was 63.6% (14 out of 22 patients). There was a significant difference in the mean number of days for IRF recovery as compared with ANC recovery (14.05 and 17.18 days), p=0.005.CONCLUSION: This study proved that IRF was more useful in predicting bone marrow recovery in a patient with acute leukemia post induction chemotherapy compared with ANC. The IRF is not affected by infection, is easily measured, and inexpensive; thus, it is a reliable parameter to evaluate bone marrow reconstitution.