PT  - JOURNAL ARTICLE
AU  - Elgamal, Essam A.
AU  - Elwatidy, Sherif M.
AU  - Alhabib, Amro F.
AU  - Jamjoom, Zain B.
AU  - Murshid, Waleed R.
AU  - Hassan, Hamdy H.
AU  - Salih, Mustafa A.
TI  - Agenesis of the corpus callosum associated with spinal open neural tube defect
DP  - 2014 Dec 01
TA  - Saudi Medical Journal
PG  - S57--S63
VI  - 35
IP  - Supplement 1
4099  - http://smj.org.sa/content/35/Supplement_1/S57.short
4100  - http://smj.org.sa/content/35/Supplement_1/S57.full
SO  - Saudi Med J2014 Dec 01; 35
AB  - OBJECTIVE: To ascertain the incidence and clinical implications of agenesis of the corpus callosum (ACC) in spinal open neural tube defects (SONTD).METHODS: All cases of SONTD registered at the Spina Bifida Clinic in King Khalid University Hospital, Riyadh, Saudi Arabia between 1995 and 2010 were retrospectively reviewed, and mid-sagittal MRI of the corpus callosum (CC) area was analyzed in each case. Neurodevelopmental outcome was classified as poor in children with seizures, severe neurodevelopmental impairment, or death.RESULTS: Thirty-eight patients (45.8%) with ACC were identified among 83 cases with SONTD. Patients' age ranged between one and 16 years. Total ACC was found in 10 patients, partial ACC in 25, and in 3 patients, the CC was hypoplastic. Active hydrocephalus was an associated finding in 9 out of 10 patients with total ACC, 22 out of 25 with partial ACC, and in all patients with hypoplasia of the CC. Thirteen patients (34.2%) had normal intellectual function, whereas 24 patients presented with learning disability, epilepsy, or poor intellectual function; and one patient died of respiratory failure.CONCLUSION: Agenesis of the corpus callosum is found in a significant portion of patients with SONTD. When associated with hydrocephalus, its presence affects neuro-developmental outcome.