RT Journal Article
SR Electronic
T1 Agenesis of the corpus callosum associated with spinal open neural tube defect
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP S57
OP S63
VO 35
IS Supplement 1
A1 Elgamal, Essam A.
A1 Elwatidy, Sherif M.
A1 Alhabib, Amro F.
A1 Jamjoom, Zain B.
A1 Murshid, Waleed R.
A1 Hassan, Hamdy H.
A1 Salih, Mustafa A.
YR 2014
UL http://smj.org.sa/content/35/Supplement_1/S57.abstract
AB OBJECTIVE: To ascertain the incidence and clinical implications of agenesis of the corpus callosum (ACC) in spinal open neural tube defects (SONTD).METHODS: All cases of SONTD registered at the Spina Bifida Clinic in King Khalid University Hospital, Riyadh, Saudi Arabia between 1995 and 2010 were retrospectively reviewed, and mid-sagittal MRI of the corpus callosum (CC) area was analyzed in each case. Neurodevelopmental outcome was classified as poor in children with seizures, severe neurodevelopmental impairment, or death.RESULTS: Thirty-eight patients (45.8%) with ACC were identified among 83 cases with SONTD. Patients' age ranged between one and 16 years. Total ACC was found in 10 patients, partial ACC in 25, and in 3 patients, the CC was hypoplastic. Active hydrocephalus was an associated finding in 9 out of 10 patients with total ACC, 22 out of 25 with partial ACC, and in all patients with hypoplasia of the CC. Thirteen patients (34.2%) had normal intellectual function, whereas 24 patients presented with learning disability, epilepsy, or poor intellectual function; and one patient died of respiratory failure.CONCLUSION: Agenesis of the corpus callosum is found in a significant portion of patients with SONTD. When associated with hydrocephalus, its presence affects neuro-developmental outcome.