PT  - JOURNAL ARTICLE
AU  - Rafay, Akbar M.
TI  - Comparative in-vitro activity of trovafloxacin and other related drugs against isolates of streptococcus oralis
DP  - 2001 Mar 01
TA  - Saudi Medical Journal
PG  - 238--243
VI  - 22
IP  - 3
4099  - http://smj.org.sa/content/22/3/238.short
4100  - http://smj.org.sa/content/22/3/238.full
SO  - Saudi Med J2001 Mar 01; 22
AB  - OBJECTIVE: The in-vitro activity of trovafloxacin a new quinolone was compared with that of ciprofloxacin, erythromycin, various b-lactam and other appropriate antibiotics such as vancomycin, teicoplanin and clindamycin against 60 isolates of S. oralis.METHODS: Minimal inhibitory concentration was performed using the agar dilution technique and micro-titer method. In addition minimal bactericidal concentration and time-kill studies were carried out to estimate the bactericidal activity of trovafloxacin against S. oralis isolates.RESULTS: Trovafloxacin showed a four-fold increase in activity over ciprofloxacin, with a narrow minimal inhibitory concentration range, MIC50 and mode values of 0.25 mg/l. Although the minimal inhibitory concentrations of trovafloxacin for S.oralis were relatively high compared to all the antibiotics tested. The in-vitro bactericidal activity of Trovafloxacin was greater than all other antibiotics against S. oralis. Five out of 10 isolates showed there was a 100% kill within 6 hours of contact; in all other cases, the kill time was between 6 and 24 hours.CONCLUSION: Overall, trovafloxacin showed superior minimal inhibitory concentration, bactericidal concentration and kill time when compared with different antibiotics.