RT Journal Article SR Electronic T1 Management of Crigler-Najjar Syndrome type I JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 486 OP 489 VO 22 IS 6 A1 Haider A. Al-Shurafa A1 Atef F. Bassas A1 Dieter C. Broering A1 Xavier G. Rogiers A1 Sami H. Wali A1 Martin M. Burdelski YR 2001 UL http://smj.org.sa/content/22/6/486.abstract AB Crigler-Najjar Syndrome type I is a rare congenital disease with high mortality and morbidity rates due to brain complications. It has been treated by life-long phototherapy until the era of liver transplantation. Liver transplantation is currently the only curative treatment for this syndrome. Liver transplantation prevents the severe neurological complications that are the main cause of life-long disability in Crigler-Najjar Syndrome type I. The ideal age for transplantation is 3-5 years. Despite the advent of auxiliary transplantation we believe that orthotopic liver transplantation is the optimal treatment and the ideal method of liver transplantation for Crigler-Najjar Syndrome type I.