%0 Journal Article %A Nadima S. Shegem %A Abeer M. Alsheek Nasir %A Anwar M. Batieha %A Hatem El-Shanti %A Kamel M. Ajlouni %T Effects of short term metformin administration on androgens in diabetic men %D 2004 %J Saudi Medical Journal %P 75-78 %V 25 %N 1 %X OBJECTIVE: Metformin, an oral hypoglycemic agent, has several other metabolic and hormonal effects. This study aims at identifying the metabolic effect of metformin on androgens in diabetic men.METHODS: The study was conducted at The National Center for Diabetes Endocrinology and Genetics, Jordan University Hospital, Amman, Jordan from April 2001 to September 2001. We studied 15 men with type 2 diabetes mellitus by measuring fasting serum glucose, insulin, glycosylated hemoglobin, total and free testosterone, sex hormone binding globulin, dehydroepiandrosterone sulphate, 17-OH progesterone, luteinizing hormone, and follicle stimulating hormone before and after a short course of metformin.RESULTS: There was a significant decrease in fasting serum glucose and glycosylated hemoglobin and increase in the level of 17-OH progesterone. The remainder of the measured parameters did not show any significant change. Although serum glucose and glycosylated hemoglobin decreased insulin levels were not changed.CONCLUSION: In contrast to normal men there was no change in androgen levels in diabetics but the 17-OH progesterone was elevated. %U https://smj.org.sa/content/smj/25/1/75.full.pdf