RT Journal Article
SR Electronic
T1 Thyroiditis induced by interferon in dialysis
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 96
OP 98
VO 21
IS 1
A1 Al-Harbi, Ali S.
A1 Mansy, Hatem
A1 Moloney, John
YR 2000
UL http://smj.org.sa/content/21/1/96.abstract
AB We describe a dialysis patient who acquired acute Hepatitis C infection. Her primary renal disease was systemic lupus erythromatosis. She was having goitre but clinically euthyroid and her thyroid function test was normal. To avoid long term complications of Hepatitis C we elected to treat her with Interferon 3 million units subcutaneously 3 times a week. During treatment she developed some transient side effects initially which subsided but later she felt pressure symptoms around her neck. When we checked her TSH and thyroid antibodies these were elevated. Though this could be related to HCV, rarely, but we think the thyroid change is mostly related to Interferon. Some possible explanation of the effect of Interferon on thyroid have been reviewed and we think patients getting such drugs should be under close monitoring to avoid permanent thyroid dysfunction.