RT Journal Article
SR Electronic
T1 Alpha-1 antitrypsin phenotypes in patients with lung, prostate and breast cancer
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 186
OP 189
VO 25
IS 2
A1 El-Akawi, Zeyad J.
A1 Al-Hindawi, Fatin K.
YR 2004
UL http://smj.org.sa/content/25/2/186.abstract
AB OBJECTIVE: Determination of Alpha1-antitrypsin (alpha1-AT) phenotypes in Jordanian patients with lung, prostate and breast cancer to find a prevalent phenotype that could be recommended for the early diagnosis of cancer.METHODS: This study was conducted at Jordan University of Science and Technology, Irbid, Jordan, during the period May 2001 to May 2002. Alpha1-AT phenotypes for 83 Jordanian cancer patients distributed as follows, 25 lung cancer, 25 prostate cancer and 33 with breast cancer, were tested using isoelectric focusing gel electrophoresis and immunofixation techniques.RESULTS: Isoelectric focusing results demonstrated that 96% of lung cancer patients were of PiMM phenotype and 4% of PiFM phenotype. All prostate cancer patients (100%) were found to be of PiMM phenotype. Phenotypes of breast cancer patients were 94% PiMM, 3% PiFM and 3% PiMS.CONCLUSION: These findings demonstrated that there were no significant differences in the distribution of alpha1-AT phenotypes among Jordanian patients with lung, prostate and breast cancer and they matched those reported for healthy individuals. Thus, we cannot recommend a given alpha1-AT phenotype for early diagnosis of the above mentioned types of cancer.