PT  - JOURNAL ARTICLE
AU  - Zargar, Abdul H.
AU  - Laway, Bashir A.
AU  - Masoodi, Shariq R.
AU  - Salahuddin, Mohammad
AU  - Ganie, Mohammad A.
AU  - Bhat, Mohammad H.
AU  - Wani, Arshad I.
AU  - Bashir, Mir I.
TI  - Clinical and endocrine aspects of pituitary tumors
DP  - 2004 Oct 01
TA  - Saudi Medical Journal
PG  - 1428--1432
VI  - 25
IP  - 10
4099  - http://smj.org.sa/content/25/10/1428.short
4100  - http://smj.org.sa/content/25/10/1428.full
SO  - Saudi Med J2004 Oct 01; 25
AB  - OBJECTIVE: To study the clinical spectrum and endocrine profile of pituitary tumors presenting to a tertiary care endocrine center.METHODS: Retrospective analysis of clinical and hormonal data of patients with pituitary tumors admitted in the Endocrinology Department of Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir India between January 1989 and December 1998.RESULTS: Over a period of one decade, 75 subjects were diagnosed to have pituitary tumors. Somatotroph adenoma was the most common pituitary mass lesion seen (44/75) and followed in the decreasing order of frequency, by non-functioning pituitary tumor (12/75), prolactinoma (11/75) and corticotroph adenoma (8/75). Overall there was a male preponderance (male to female ratio was 41:34). Subjects with somatotroph adenoma presented with classical features of acromegaly: mean fasting and post glucose suppression growth hormone levels were 34.04+/-11.67 and 36.47+/-6.64 ng/ml. Eleven subjects (9 females and 2 males) had prolactinoma; females presented with the classical symptom complex of amenorrhea-galactorrhea while males presented with headache, visual disturbances and impotence. The 12 subjects with nonfunctioning pituitary tumors presented with features of mass lesion. Of the 8 subjects (6 females and 2 males) with corticotroph adenomas, 2 were confirmed to have periodic hormonogenesis.CONCLUSION: In an endocrine center, functioning pituitary tumors are more often seen than non-functioning tumors.