@article {Al-Shurafa265, author = {Haider A. Al-Shurafa and Muaffak T. Jawdat and Atef F. Bassas and Xavier C. Rogiers and Wolf O. Bechstein}, title = {Innovations in pancreas transplantation}, volume = {23}, number = {3}, pages = {265--271}, year = {2002}, publisher = {Saudi Medical Journal}, abstract = {Pancreas transplantation is currently the curative treatment for type 1 diabetes mellitus. It aims at providing physiological insulin replacement therapy in type 1 diabetes mellitus. The goal is thereby also to prevent secondary complications of diabetes. Long term control of glucose metabolism has only been achieved by pancreas transplantation. As a result of improvements in the surgical techniques and the efficacy of immunosuppression, the patient and graft survival rates have improved dramatically over the last 2 decades. As a result, pancreas transplantation, as part of simultaneous pancreas and kidney transplantation, pancreas after kidney transplantation, and exceptionally pancreas transplantation alone, became the standard therapeutic option for patients with type 1 diabetes mellitus with end-stage renal disease. In this article we review the pancreas transplantation methods, indications, techniques, and the short as well as the long outcomes of treatment.}, issn = {0379-5284}, URL = {https://smj.org.sa/content/23/3/265}, eprint = {https://smj.org.sa/content/23/3/265.full.pdf}, journal = {Saudi Medical Journal} }