@article {Shome464, author = {Durjoy K. Shome and Hussain Al-Mukharraq and Najat Mahdi and Ghada Ameen and Eman Farid}, title = {Clinicopathological aspects of Chediak-Higashi syndrome in the accelerated phase}, volume = {23}, number = {4}, pages = {464--466}, year = {2002}, publisher = {Saudi Medical Journal}, abstract = {This report describes clinical and laboratory features of a case of Chediak-Higashi syndrome that presented in the accelerated phase of the disorder. This female infant presented with a fever, marked neutropenia, large cytoplasmic granules in leukocytes and a constellation of features that suggested a virus-associated hemophagocytic syndrome. The clinical course was marked by limited response to the therapeutic agents that included ascorbate, cytotoxic agents and granulocyte colony-stimulating factor.}, issn = {0379-5284}, URL = {https://smj.org.sa/content/23/4/464}, eprint = {https://smj.org.sa/content/23/4/464.full.pdf}, journal = {Saudi Medical Journal} }