PT  - JOURNAL ARTICLE
AU  - Shome, Durjoy K.
AU  - Al-Mukharraq, Hussain
AU  - Mahdi, Najat
AU  - Ameen, Ghada
AU  - Farid, Eman
TI  - Clinicopathological aspects of Chediak-Higashi syndrome in the accelerated phase
DP  - 2002 Apr 01
TA  - Saudi Medical Journal
PG  - 464--466
VI  - 23
IP  - 4
4099  - http://smj.org.sa/content/23/4/464.short
4100  - http://smj.org.sa/content/23/4/464.full
SO  - Saudi Med J2002 Apr 01; 23
AB  - This report describes clinical and laboratory features of a case of Chediak-Higashi syndrome that presented in the accelerated phase of the disorder. This female infant presented with a fever, marked neutropenia, large cytoplasmic granules in leukocytes and a constellation of features that suggested a virus-associated hemophagocytic syndrome. The clinical course was marked by limited response to the therapeutic agents that included ascorbate, cytotoxic agents and granulocyte colony-stimulating factor.