TY - JOUR T1 - Clinicopathological aspects of Chediak-Higashi syndrome in the accelerated phase JF - Saudi Medical Journal JO - Saudi Med J SP - 464 LP - 466 VL - 23 IS - 4 AU - Durjoy K. Shome AU - Hussain Al-Mukharraq AU - Najat Mahdi AU - Ghada Ameen AU - Eman Farid Y1 - 2002/04/01 UR - http://smj.org.sa/content/23/4/464.abstract N2 - This report describes clinical and laboratory features of a case of Chediak-Higashi syndrome that presented in the accelerated phase of the disorder. This female infant presented with a fever, marked neutropenia, large cytoplasmic granules in leukocytes and a constellation of features that suggested a virus-associated hemophagocytic syndrome. The clinical course was marked by limited response to the therapeutic agents that included ascorbate, cytotoxic agents and granulocyte colony-stimulating factor. ER -