PT  - JOURNAL ARTICLE
AU  - Basgul, Elif
AU  - Bahadir, Betul
AU  - Celiker, Varol
AU  - Karagoz, Ayse H.
AU  - Hamaloglu, Erhan
AU  - Aypar, Ulku
TI  - Effects of low and high intra-abdominal pressure on immune response in laparoscopic cholecystectomy
DP  - 2004 Dec 01
TA  - Saudi Medical Journal
PG  - 1888--1891
VI  - 25
IP  - 12
4099  - http://smj.org.sa/content/25/12/1888.short
4100  - http://smj.org.sa/content/25/12/1888.full
SO  - Saudi Med J2004 Dec 01; 25
AB  - OBJECTIVE: Immunosuppression is directly related to the degree of trauma. The aim of this study is to compare the effects of low and high intra-abdominal pressure on immune response in moderate surgical trauma.METHODS: Twenty-two patients, scheduled for laparoscopic cholecystectomy, were randomly allocated to one of 2 groups according to intra-abdominal pressure: low and high intra-abdominal pressure. This study was conducted in the Hacettepe University Faculty of Medicine, Operation Room, Ankara, Turkey. Serum interleukin (IL)-2 and IL-6 levels were measured.RESULTS: Serum IL-2 showed a significant decrease before the incision in high intra-abdominal pressure group. The increase in serum IL-6 at the end of surgery and postoperatively was lower in low intra-abdominal pressure group.CONCLUSION: These results, can be interpreted as the immune system, are less depressed when there is lower intra-abdominal pressure. This may have clinical implications in immunocompromised patients.