RT Journal Article
SR Electronic
T1 The effect of concurrent use of hepatitis B and Bacille Calmette-Guerin vaccination on anti-hepatitis B response
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1939
OP 1942
VO 25
IS 12
A1 Artan, Reha
A1 Erol, Meltem
A1 Velipasaoglu, Sevtap
A1 Yegin, Olcay
YR 2004
UL http://smj.org.sa/content/25/12/1939.abstract
AB OBJECTIVE: Bacille Calmette-Guerin (BCG) is given at 2-months of age; diphtheria toxoid, tetanus toxoid, whole cell pertussis, oral polio are given at 2, 3, 4 months, and hepatitis B virus (HBV) vaccine is given at 3, 4, 9 months of age. The aim was to evaluate the sero-protection rate of HBV vaccine which has been given at 2, 3, and 9 months of age and coincided with BCG vaccine at the first dose.METHODS: Hepatitis B virus vaccine was administered to 3 groups of infants at 2, 3, 9 months (n=20), 3, 4, 9 months (n=20) concurrently with BCG or other vaccines, and at 0, 1, 6 months with no other coinciding another vaccine (n=20). These 60 infants who were born between June 2001 and September 2001 have been vaccinated at the Akdeniz University School of Medicine, Antalya, Turkey. Antibodies to hepatitis B surface antigen analyzed by enzyme-linked immunosorbent assay.RESULTS: The simultaneous administration of BCG and HBV vaccines did not influence the immune response to HBV vaccine. We showed that all 3 schedules can induce the sero-protective levels of antibody concentrations to HBV both one month and one year after the vaccination.CONCLUSION: Bacille Calmette-Guerin and HBV vaccinations can be performed at the same time in endemic countries.