RT Journal Article
SR Electronic
T1 The role of vitamin E in the prevention of coronary events and stroke. Meta-analysis of randomized controlled trials
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1808
OP 1814
VO 25
IS 12
A1 Alkhenizan, Abdullah H.
A1 Al-Omran, Mohammed A.
YR 2004
UL http://smj.org.sa/content/25/12/1808.abstract
AB Cardiovascular disease CVD is the leading cause of morbidity and mortality in the world. Vitamin E as an anti-oxidant vitamin, was suggested to have a role in the prevention of CVD. We did a meta-analysis, using the Cochrane Group Methodology, of all available randomized controlled trials RCTs to evaluate the role of vitamin E in the prevention of CVD. Nine studies met inclusion criteria, including 80,645 participants. Vitamin E supplementation was not associated with a reduction in total mortality or total CVD mortality, but it was associated with a small statistically significant reduction in non-fatal myocardial infarction in patients with pre-existing coronary artery disease. Prophylactic use of vitamin E in doses ranging between 50-800 IU was not associated with any increase in the incidence of serious side effects.