RT Journal Article
SR Electronic
T1 Immunohistochemical evaluation of periprosthetic membrane from loose cemented and uncemented total hip arthroplasty
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 429
OP 433
VO 26
IS 3
A1 Atilla, Bulent
A1 Atilla, Pergin
A1 Tokgozoglu, Ahmet M.
A1 Cakar, Ayse N.
A1 Alpaslan, Ahmet M.
YR 2005
UL http://smj.org.sa/content/26/3/429.abstract
AB OBJECTIVE: Evaluate the cellular mechanisms responsible for the aseptic loosening of total hip replacements.METHODS: Twenty periprosthetic membranes were collected during revision procedures at the Department of Orthopedics, Hacettepe University, Ankara, Turkey, during 1998 to 1999. Arthroplasties with polyethylene components and without polyethylene components were examined under light microscopy and immunohistochemically using the indirect immunoperoxidase technique into 2 different groups.RESULTS: Immunohistochemical analysis with monoclonal antibodies reactive to certain cell surface antigens (CD45, CD44, CD98, CD31, CD26, CD71) revealed different morphological characteristics regarding the adjacent fibrosis, leukocyte activation, and immunologic response.CONCLUSION: These findings suggested the role of different cellular mechanisms in each group.