PT  - JOURNAL ARTICLE
AU  - Ibrahim A. Al-Dabbous
TI  - Acute chest syndrome
DP  - 2002 Sep 01
TA  - Saudi Medical Journal
PG  - 1037--1044
VI  - 23
IP  - 9
4099  - http://smj.org.sa/content/23/9/1037.short
4100  - http://smj.org.sa/content/23/9/1037.full
SO  - Saudi Med J2002 Sep 01; 23
AB  - Acute chest syndrome is an acute pulmonary illness in patients with sickle cell disease. It is a common problem, causing significant morbidity and mortality. Many factors may cause this syndrome. Treatment is primarily supportive. Therapy includes hydration, analgesia, supplemental oxygen, antibiotics, blood transfusion and mechanical ventilation. Early detection and aggressive management may limit its severity and prevent its complications. This article reviews the current information for its definition, frequency, pathogenesis, clinical features, complications, investigations, management and prevention. Recent advances in management of acute and recurrent attacks will be discussed.