RT Journal Article
SR Electronic
T1 Lipid profile in patients with coronary artery disease
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1054
OP 1058
VO 23
IS 9
A1 Fares H. Haddad
A1 Ahmed A. Omari
A1 Qasem M. Shamailah
A1 Omar M. Malkawi
A1 Alia I. Shehab
A1 Hana K. Mudabber
A1 Mohammed K. Shubaki
YR 2002
UL http://smj.org.sa/content/23/9/1054.abstract
AB OBJECTIVE: To determine the lipid profile and to identify and stratify risk factors in diabetic and non-diabetic patients with proven coronary artery disease at King Hussein Medical Center, Amman, Jordan.METHODS: One hundred and ninety-two patients who were admitted to Queen Alia Heart Institute, Amman, Jordan, proving to have coronary artery disease (CAD) by angiogram, with a mean age of 54 ± 22 years were studied. Seventy-seven patients were diabetics and 115 non-diabetics. Their lipid profiles (T-Cholesterol, high density lipoprotein level (HDL-C), low density lipoprotein level (LDL-C), triglyceride, glucose, glycosylated hemoglobin) and thyroid function test were compared to a control group of 162 individuals with no cardiac events or diabetes, mean age 48.9 ± 18 years. Prevalence of hyperlipidemia was calculated. Patients with high thyroid stimulating hormone were excluded.RESULTS: The mean (±standard deviation) plasma cholesterol for the group with CAD is 231.43 ± 57.99 mg/dl versus 202.8 ± 36.58 in the control group (p<0.0003). High density lipoprotein 35.98 ± 9.37 versus 44.43 ± 8.34 (p=0.00011). Low density lipoprotein 146.75 ± 50.93 versus 118.97 ± 45.9 (p=0.003). Triglyceride level 246.95 ± 142.1 versus 164 mg/l ± 93.78 (p=0.0002). Thyroid stimulating hormone level was 1.55 ± 0.9 versus 1.51 ± 0.89 ng/l in control group (p=0.35 NS), HbA1c in diabetic group 7 ± 2.3%. The prevalence of high plasma cholesterol, triglycerides (TG), LDL-C and low HDL-C was 60.9%, 68.3%, 63.5% and 48.4%. Inter-group comparison of patients with CAD (diabetics versus non-diabetics) revealed higher TG level in the diabetic group and statistically significant difference of the HDL and LDL levels between the 2 groups in favor of diabetic group explained by higher percentage of patients on anti-hyperlipidemic drugs than non-diabetics. More females with CAD were found in the diabetic group versus non-diabetic group (16.9% versus 6.1%. z=2.4027 p=0.00820).CONCLUSION: Jordanian patients with CAD have higher cholesterol, LDL-C, Triglyceride and lower HDL-C levels than the control group which comes in accordance of other studies. Hyperlipidemia remains the strongest risk factor for CAD. Diabetic females are at higher risk for CAD versus non-diabetics with the same lipid profile. Aggressive treatment of hyperlipidemia is of paramount importance to reduce the morbidity and mortality of cardiac events in diabetic and non-diabetic patients.