PT  - JOURNAL ARTICLE
AU  - Nasser Al-Rajhi
AU  - Mohammad Saleem
AU  - Abdullah S. Al-Amro
AU  - Ashraf M. El-Enbaby
AU  - Gamal A. El-Husseiny
AU  - Zeyad Z. Mahasin
AU  - Kalid M. Taibah
AU  - Ali M. Al-Zahrani
TI  - Stage IV oral cavity carcinoma. Is conventional radical treatment an option?
DP  - 2002 Sep 01
TA  - Saudi Medical Journal
PG  - 1095--1098
VI  - 23
IP  - 9
4099  - http://smj.org.sa/content/23/9/1095.short
4100  - http://smj.org.sa/content/23/9/1095.full
SO  - Saudi Med J2002 Sep 01; 23
AB  - OBJECTIVE: To evaluate the outcome of radical treatment for patients with stage IV squamous cell carcinoma of the oral cavity.METHODS: Using head and neck tumor database, 57 patients with stage IV non-metastatic invasive squamous cell carcinoma of the oral cavity treated with curative intent at King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia, between July 1992 and June 1998, were identified and retrospectively reviewed.RESULTS: Our cohort of patients consisted of 33 males and 24 females, with a median age of 65 years. The primary sites were alveolus (26), tongue (22), buccal mucosa (6), floor of mouth (2) and retromolar trigone (one). Definitive radiotherapy was used in 7 patients, surgery in 17 and combined modality in 33. With a median follow-up for surviving patients of 53-months, the actuarial 5-year overall survival and relapse free survival was 20% and 14%. Tumors arising from the alveolus showed a better outcome as compared to the rest of oral cavity sites with an overall survival and relapse free survival of 32% and 26% compared to 8% and 4% (p value=0.0057 and 0.0038).CONCLUSION: Advanced oral cavity tumors are aggressive neoplasms with a poor outcome to conventional treatment modalities. New approaches like neoadjuvant or concurrent chemoradiotherapy with or without surgery need to be considered and evaluated in prospective studies.