PT  - JOURNAL ARTICLE
AU  - Alfaresi, Mubarak S.
AU  - Eltom, Abdulla A.
AU  - Alshaikh, Saeed S.
AU  - Buchel, Elwin H.
AU  - Saeed, Lamya S.
AU  - Aljenaibi, Monther M.
TI  - Molecular prevalence of point mutations conferring resistance to clarithromycin in Helicobacter pylori in the United Arab Emirates
DP  - 2005 May 01
TA  - Saudi Medical Journal
PG  - 763--766
VI  - 26
IP  - 5
4099  - http://smj.org.sa/content/26/5/763.short
4100  - http://smj.org.sa/content/26/5/763.full
SO  - Saudi Med J2005 May 01; 26
AB  - OBJECTIVE: The aim of the study was to find the prevalence of point mutations conferring resistance to clarithromycin in Helicobacter pylori (H. pylori) in the United Arab Emirates.METHODS: Gastric biopsy samples were obtained from 9 dyspeptic patients attending the endoscopy department in Zayed Military Hospital, Abu-Dhabi, UAE during the period from January to September 2004. Real-time polymerase chain reaction (PCR) was carried out for these biopsies to determine the point mutations.RESULTS: Of the 55 (60%) real-time biopsies that were PCR positive for H. pylori, 36 (65.5%) were found to have mutant genes. The A(2142/43)G mutation was more common (63.6%) than the A(2142)C mutation (18.2%).CONCLUSION: Point mutations A(2442/43)G and A(2142)C and the combination of both were common among our patients. Perhaps the highest reported yet. Mutation at A(2142/43)G is far more common than mutation at A(2142)C.