PT  - JOURNAL ARTICLE
AU  - Saricaoglu, Fatma
AU  - Akinci, Seda B.
AU  - Celiker, Varol
AU  - Aypar, Ulku
TI  - The effect of acute normovolemic hemodilution and acute hypervolemic hemodilution on coagulation and allogeneic transfusion
DP  - 2005 May 01
TA  - Saudi Medical Journal
PG  - 792--798
VI  - 26
IP  - 5
4099  - http://smj.org.sa/content/26/5/792.short
4100  - http://smj.org.sa/content/26/5/792.full
SO  - Saudi Med J2005 May 01; 26
AB  - OBJECTIVE: In this study, acute normovolemic hemodilution (ANH) and hypervolemic hemodilution (HHD) were compared with no hemodilution with regards to the effectiveness in blood usage and coagulation parameters.METHODS: The study was performed from February to August 2001 at Hacettepe University Hospital, Ankara, Turkey. Thirty patients undergoing hip arthroplasty surgery were prospectively randomized into: ANH group [autologous blood 15 mL kg-1 was withdrawn and replaced by 6% hydroxyethylstarch (HES)] or HHD group (HES was administered without removal of any autologous blood) or the control group (no hemodilution). In all groups, blood was given when hemoglobin concentration was <9 g dl-1.RESULTS: Three groups were clinically similar regarding blood loss, mean arterial pressures and coagulation parameters. But allogeneic transfusion requirements were significantly less in hemodilution groups (20% in ANH, 40% in HHD) compared to the control group (100% of patients).CONCLUSION: We conclude that hemodilution (both ANH and HHD) decreases the demand for homologous blood without adversely affecting hemodynamics or coagulation parameters and HHD seems to be a simple and valuable alternative to ANH in orthopedic patient undergoing hip replacement.