PT  - JOURNAL ARTICLE
AU  - Ayyub, Muhammad
AU  - Barlas, Shahid
AU  - Iqbal, Mohammad
AU  - Khurshid, Samira M.
TI  - Diffuse alveolar hemorrhages and hemorrhagic pleural effusion after thrombolytic therapy with streptokinase for acute myocardial infarction
DP  - 2003 Feb 01
TA  - Saudi Medical Journal
PG  - 217--220
VI  - 24
IP  - 2
4099  - http://smj.org.sa/content/24/2/217.short
4100  - http://smj.org.sa/content/24/2/217.full
SO  - Saudi Med J2003 Feb 01; 24
AB  - Thrombolytic therapy with streptokinase is commonly used in acute myocardial infarction and has markedly reduced morbidity and mortality from this condition. However, it can cause various hemorrhagic and immunological complications.We report a patient who developed diffuse pulmonary hemorrhages and bilateral hemorrhagic pleural effusion after thrombolytic therapy with streptokinase for acute myocardial infarction. This was recognized by a drop of hematocrit, pulmonary infiltrates, hemorrhagic pleural effusion and hypoxemia. The diagnosis was confirmed by demonstration of iron-laden macrophages (siderophages) in bronchoalveolar lavage. The patient required mechanical ventilation and recovered successfully. This combination of pulmonary hemorrhages and hemorrhagic pleural effusion following streptokinase therapy is extremely unusual and has not been reported previously.