RT Journal Article
SR Electronic
T1 Diffuse alveolar hemorrhages and hemorrhagic pleural effusion after thrombolytic therapy with streptokinase for acute myocardial infarction
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 217
OP 220
VO 24
IS 2
A1 Ayyub, Muhammad
A1 Barlas, Shahid
A1 Iqbal, Mohammad
A1 Khurshid, Samira M.
YR 2003
UL http://smj.org.sa/content/24/2/217.abstract
AB Thrombolytic therapy with streptokinase is commonly used in acute myocardial infarction and has markedly reduced morbidity and mortality from this condition. However, it can cause various hemorrhagic and immunological complications.We report a patient who developed diffuse pulmonary hemorrhages and bilateral hemorrhagic pleural effusion after thrombolytic therapy with streptokinase for acute myocardial infarction. This was recognized by a drop of hematocrit, pulmonary infiltrates, hemorrhagic pleural effusion and hypoxemia. The diagnosis was confirmed by demonstration of iron-laden macrophages (siderophages) in bronchoalveolar lavage. The patient required mechanical ventilation and recovered successfully. This combination of pulmonary hemorrhages and hemorrhagic pleural effusion following streptokinase therapy is extremely unusual and has not been reported previously.