PT  - JOURNAL ARTICLE
AU  - Alenzi, Faris Q.
TI  - Apoptosis and diseases. Regulation and clinical relevance
DP  - 2005 Nov 01
TA  - Saudi Medical Journal
PG  - 1679--1690
VI  - 26
IP  - 11
4099  - http://smj.org.sa/content/26/11/1679.short
4100  - http://smj.org.sa/content/26/11/1679.full
SO  - Saudi Med J2005 Nov 01; 26
AB  - It is increasingly clear that apoptosis plays a central role in the pathogenesis of several human diseases. For instance, an increase in apoptosis leads to cell loss accompanied by neurodegenerative diseases, whereas we know that genetically determined defects of apoptosis result in deregulated cell proliferation, typical of cancer. Hence, apoptosis may be relevant as therapeutic targets for many human diseases. This article reviews briefly the regulation and the clinical relevance of apoptotic mechanisms in several different human diseases.