RT Journal Article
SR Electronic
T1 Apoptosis and diseases. Regulation and clinical relevance
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1679
OP 1690
VO 26
IS 11
A1 Alenzi, Faris Q.
YR 2005
UL http://smj.org.sa/content/26/11/1679.abstract
AB It is increasingly clear that apoptosis plays a central role in the pathogenesis of several human diseases. For instance, an increase in apoptosis leads to cell loss accompanied by neurodegenerative diseases, whereas we know that genetically determined defects of apoptosis result in deregulated cell proliferation, typical of cancer. Hence, apoptosis may be relevant as therapeutic targets for many human diseases. This article reviews briefly the regulation and the clinical relevance of apoptotic mechanisms in several different human diseases.