@article {Zhongyin161, author = {Zhou Zhongyin and Luo Hesheng and Liu Jun and Chen Jihong}, title = {Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas}, volume = {27}, number = {2}, pages = {161--164}, year = {2006}, publisher = {Saudi Medical Journal}, abstract = {OBJECTIVE: To investigate the relationship of serum lipids and apolipoprotein (apoE) gene polymorphism to colorectal adenomas.METHODS: This study took place in the Department of Gastroenterology, Renmin Hospital of Wuhan University, PR China from June 2003 to March 2005. Ninety-eight patients with colorectal adenomas and 40 healthy subjects were enrolled, and their serum levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were determined. The apoE gene polymorphism was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).RESULTS: Serum TC levels of colorectal adenomas group (5.32 {\textpm} 0.85~mmol/L), distal colorectal adenomas group (5.58 {\textpm} 0.63~mmol/L), and villous adenoma group (5.49 {\textpm} 0.69~mmol/L) were higher than the control group (4.28 {\textpm} 0.62~mmol/L, p=0.016), proximal colorectal adenomas group (4.82 {\textpm} 0.58~mmol/L, p=0.038) and non-villous adenoma group (4.76 {\textpm} 0.58~mmol/L, p=0.03). Serum HDL-C levels of colorectal adenomas group (1.39 {\textpm} 0.25~mmol/L) were lower than the control group (1.51 {\textpm} 0.29~mmol/L) (p=0.035). Serum lipids levels of each genotype in colorectal adenomas group were not statistically significant. Apolipoprotein E3/E4 genotypic frequency in colorectal adenomas group (7.1\%) was lower than the control group (17.5\%) (p=0.012).CONCLUSION: The findings suggest that altered lipid metabolism may be differentially associated with colorectal adenomas and the persons with apoE E3/E4 genotype have lower risk suffering from colorectal adenomas than those with other genotypes.}, issn = {0379-5284}, URL = {https://smj.org.sa/content/27/2/161}, eprint = {https://smj.org.sa/content/27/2/161.full.pdf}, journal = {Saudi Medical Journal} }