@article {Shomaf185, author = {Maha S. Shomaf and Nidal A. Younes and Nader M. Albsoul and Ayman A. Musmar and Mohammed M. Al-Zaheri and Musleh S. Tarawneh and Ahmad S. Sroujieh}, title = {New trends in the clinicopathological features of differentiated thyroid cancer in Central Jordan}, volume = {27}, number = {2}, pages = {185--190}, year = {2006}, publisher = {Saudi Medical Journal}, abstract = {OBJECTIVE: To investigate the current trends in presentation and distribution of differentiated thyroid cancer (DTC) at the largest referral hospital for endocrine cancers in Central Jordan.METHODS: We analyzed the clinical features, management and outcome of 110 patients diagnosed with thyroid carcinoma at Jordan University Hospital, Amman, between 1996 and 2001.RESULTS: Papillary carcinoma was diagnosed in 87 patients (80\%), follicular carcinoma in 3 patients (2.7\%), Hurthle cell carcinoma in 8 patients (7.3\%), medullary carcinoma in 5 (4.5\%), and anaplastic carcinoma in 4 patients (3.6\%), metastatic cancer in 2 patients and lymphoma in one patient. Time course analysis showed an increasing trend in surgery for thyroid cancer from 28 cases in 1986-1991 to 48 in 1996-2001. As time advanced, the incidence of locally invasive disease and lymph node involvement markedly increased over the last 5~years of the study (from 28-62\%). All patients with follicular carcinoma were diagnosed in the period 1986-1994. After thyroidectomy and a follow up period of 2-15~years, 10 patients died of their disease, 4 of these died within one year from anaplastic thyroid carcinoma.CONCLUSION: The dramatic decline in the incidence of follicular thyroid carcinoma combined with the increase in the advanced forms of thyroid cancer in Central Jordan may suggest a possible environmental factor in thyroid carcinogenesis in this region. We suggest a larger scale studies and steps to investigate the etiologic factors for thyroid carcinogenesis in Central Jordan.}, issn = {0379-5284}, URL = {https://smj.org.sa/content/27/2/185}, eprint = {https://smj.org.sa/content/27/2/185.full.pdf}, journal = {Saudi Medical Journal} }