RT Journal Article
SR Electronic
T1 Clinical profile of myasthenia gravis in the Sultanate of Oman
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 774
OP 775
VO 24
IS 7
A1 Jacob, Poovathoor C.
A1 Tharakan, John T.
A1 Chand, Pratap R.
A1 Koul, Roshan L.
A1 Chacko, Alexander P.
YR 2003
UL http://smj.org.sa/content/24/7/774.abstract
AB OBJECTIVE: Clinical study and follow up of myasthenia gravis patients in Oman.METHODS: Follow up of 50 consecutive myasthenia gravis patients referred to the Sultan Qaboos University Hospital, Oman for a median period of 3 years from 1997 to 2000. We based the diagnosis on the clinical picture, repetitive nerve stimulation tests and edrophonium test. We performed a computerized tomography scan of the chest and anti-acetylcholine receptor antibodies. We reviewed the results of immuno modulatory treatment including thymectomy and compared these with other studies.RESULTS: Of 50 patients, 6 had purely ocular myasthenia. Of the 44 with generalized myasthenia, 28 had bulbar involvement and 12 required ventilatory support. Eight out of 29 thymectomized patients had drug free remission after 2 years. There was worsening of myasthenic symptoms in only one out of 8 pregnancies and deliveries.CONCLUSION: Bulbar and ventilatory involvement are more common in our series as compared with western data. Pregnancy and delivery were well tolerated.